The conference aims to create a new international venue that can unite scholars, practitioners and students from diverse fields to address various real-world challenges and opportunities using methodologies of complex systems modeling and analysis. The conference will showcase cutting-edge modeling/analysis methods, interdisciplinary applications, and innovative solutions, fostering collaboration and sparking new ideas. Its inaugural 2025 edition will have a particular focus on the applications to education and society. By integrating insights from systems science, mathematics, computer science, engineering, economics, social sciences, psychology, healthcare, education, and many others, we seek to advance understanding and application in these crucial areas. Join us to explore how multidisciplinary approaches can drive improvements in our society!